Regulation of toll-like receptor 4 signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of toll-like receptor 4 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF711, BRD3OS, and FBXO44, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF711 grouped by Regulation of toll-like receptor 4 signaling pathway-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ZNF711 →	+2.011	+0.736	<.001	.004	3	4
OVARY	BRD3OS →	-0.646	-0.592	.004	.005	3	3
BLOOD_Leukemia	FBXO44 →	-1.837	-0.247	.009	.005	3	3
BLOOD_Leukemia	MT-ND2 →	+0.578	+0.253	.009	.003	3	3
LUNG_NSCLC_LUSC	GAREM2 →	+1.445	+0.333	.006	.002	3	3
URINARY_TRACT	RAP1GDS1 →	-1.223	-1.202	.005	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF711 by Regulation of toll-like receptor 4 signaling pathway activity — SOFT_TISSUE

Explore this box plot interactively →