Toll-like receptor 4 signaling pathway

Across TCGA patient cohorts, RNA activity of the Toll-like receptor 4 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYSLTR1, CCR4, and CSF2RB, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Toll-like receptor 4 signaling pathway activity versus CYSLTR1 in SCLC (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	CYSLTR1 →	+1.241	+0.106	<.001	<.001	3	34
DLBC	CCR4 →	+3.128	+0.078	<.001	.002	3	34
SCLC	CSF2RB →	+1.747	+0.111	<.001	<.001	3	33
DLBC	ADGRE2 →	+1.608	+0.056	<.001	.005	3	33
LAML	FGL2 →	+2.417	+0.092	<.001	<.001	3	33
SCLC	WDFY4 →	+1.439	+0.097	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034142 vs CYSLTR1 — SCLC

Explore this scatter interactively →