Toll-like receptor 4 signaling pathway

Across TCGA patient cohorts, RNA activity of the Toll-like receptor 4 signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HCLS1, LPXN, and APOL3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Toll-like receptor 4 signaling pathway activity versus HCLS1 in GBM (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HCLS1 →	+0.723	+0.073	<.001	<.001	3	9
UCEC	LPXN →	+0.604	+0.082	<.001	<.001	3	9
BRCA	APOL3 →	+0.893	+0.041	<.001	<.001	3	9
HNSC	NFATC2 →	+0.466	+0.061	<.001	.004	3	9
GBM	INPP5D →	+0.546	+0.084	<.001	<.001	3	9
LSCC	INPP5D_S243 →	+0.613	+0.068	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034142 vs HCLS1 — GBM

Explore this scatter interactively →