Toll-like receptor 4 signaling pathway

Across TCGA patient cohorts, RNA activity of the Toll-like receptor 4 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBE2L6, HLA-F, and SLC31A2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Toll-like receptor 4 signaling pathway activity versus UBE2L6 in LUAD (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	UBE2L6 →	+0.498	+0.301	.003	.005	3	5
LSCC	HLA-F →	+0.808	+0.623	<.001	.003	3	5
GBM	SLC31A2 →	+0.431	+0.188	.003	<.001	2	5
LSCC	CCRL2 →	+0.647	+0.720	<.001	<.001	3	4
LSCC	UBASH3B →	+0.448	+0.544	.002	.002	3	4
LSCC	BATF2 →	+0.918	+0.568	.002	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034142 vs UBE2L6 — LUAD

Explore this scatter interactively →