Toll-like receptor 4 signaling pathway

Across TCGA patient cohorts, RNA activity of the Toll-like receptor 4 signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RIPK2_S531, SRSF9_S204, and TJP1_S329, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Toll-like receptor 4 signaling pathway activity versus RIPK2_S531 in BRCA (Pearson r = 0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RIPK2_S531 →	+0.706	+0.241	<.001	<.001	3	4
BRCA	SRSF9_S204 →	-0.622	-0.153	.004	<.001	3	4
BRCA	TJP1_S329 →	-0.571	-0.159	<.001	<.001	3	3
CCRCC	EPB41_S684 →	+0.620	+0.495	<.001	<.001	3	3
LSCC	MACF1_S6967 →	+0.539	+0.628	<.001	<.001	3	3
LSCC	SPEN_S727 →	-0.331	-0.638	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034142 vs RIPK2_S531 — BRCA

Explore this scatter interactively →