Toll-like receptor 4 signaling pathway

Across TCGA cell cohorts, RNA activity of the Toll-like receptor 4 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OAS1, OAS3, and OAS2, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Toll-like receptor 4 signaling pathway activity versus OAS1 in STOMACH (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	OAS1 →	+3.177	+0.105	.002	<.001	3	15
OVARY	OAS3 →	+1.328	+0.057	<.001	<.001	3	12
BLOOD_Myeloma	OAS2 →	+2.862	+0.070	<.001	.004	3	11
LUNG_SCLC	SP100 →	+2.857	+0.074	<.001	<.001	3	9
LUNG_SCLC	TICAM1 →	+1.133	+0.065	.001	.005	3	8
SOFT_TISSUE	IRAK2 →	+2.017	+0.090	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034142 vs OAS1 — STOMACH

Explore this scatter interactively →