Toll-like receptor 4 signaling pathway

Across TCGA cell cohorts, RNA activity of the Toll-like receptor 4 signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGAV, ACOXL-AS1, and UBXN10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ITGAV grouped by Toll-like receptor 4 signaling pathway-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ITGAV →	-0.341	-0.843	.005	.003	3	5
BREAST	ACOXL-AS1 →	+0.176	+0.781	<.001	.002	3	4
LUNG_SCLC	UBXN10 →	-0.102	-0.955	.008	.004	3	4
BREAST	DAGLB →	+0.309	+0.934	.005	.008	3	4
STOMACH	MRGBP →	+0.290	+1.895	.008	<.001	3	3
STOMACH	FUT6 →	+0.307	+1.801	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ITGAV by Toll-like receptor 4 signaling pathway activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →