Toll-like receptor 4 signaling pathway

Across TCGA cell cohorts, RNA activity of the Toll-like receptor 4 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are S100A14, ELMO3, and F2R, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Toll-like receptor 4 signaling pathway activity versus S100A14 in URINARY_TRACT (Pearson r = 0.92).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	S100A14 →	+6.288	+1.815	<.001	<.001	3	9
URINARY_TRACT	ELMO3 →	+2.988	+1.864	<.001	<.001	3	7
PANCREAS	F2R →	-2.162	-1.252	.002	.004	3	7
OESOPHAGUS	LIX1L →	-2.391	-1.440	.001	.001	3	7
LUNG_NSCLC_LUAD	GRHL2 →	+2.130	+1.352	<.001	<.001	3	7
OESOPHAGUS	FSD1L →	-1.021	-1.559	.003	.001	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034142 vs S100A14 — URINARY_TRACT

Explore this scatter interactively →