Positive regulation of toll-like receptor 3 signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of toll-like receptor 3 signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SNX29_S268, STK25, and SVIL_T657, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of toll-like receptor 3 signaling pathway activity versus SNX29_S268 in LUAD (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SNX29_S268 →	+0.766	+0.060	<.001	<.001	3	6
HNSC	STK25 →	+0.258	+0.064	<.001	<.001	3	6
LSCC	SVIL_T657 →	+0.500	+0.045	.002	.001	3	6
GBM	TBC1D2B_S155 →	+0.311	+0.041	.009	.005	3	6
LUAD	TIMM44 →	-0.223	-0.049	<.001	<.001	3	6
BRCA	TNKS1BP1_S851 →	+0.976	+0.041	<.001	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034141 vs SNX29_S268 — LUAD

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