Positive regulation of toll-like receptor 3 signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of toll-like receptor 3 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GASK1B, HNMT, and KLHDC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of toll-like receptor 3 signaling pathway activity versus GASK1B in BRCA (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GASK1B →	+1.287	+0.174	<.001	<.001	3	5
BRCA	HNMT →	+0.808	+0.176	<.001	.008	3	5
BRCA	KLHDC1 →	+0.623	+0.136	<.001	.001	3	5
BRCA	PUS1 →	-0.446	-0.211	.003	<.001	3	5
BRCA	ALG3 →	-0.351	-0.160	.001	.002	3	5
BRCA	NPDC1 →	+1.000	+0.166	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034141 vs GASK1B — BRCA

Explore this scatter interactively →