Regulation of toll-like receptor 3 signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of toll-like receptor 3 signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SRC, RSU1, and C1QBP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of toll-like receptor 3 signaling pathway activity versus SRC in OV (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SRC →	+0.300	+0.048	.005	.003	3	6
COAD	RSU1 →	+0.432	+0.038	<.001	<.001	3	6
BRCA	C1QBP →	-0.323	-0.027	<.001	<.001	3	6
LUAD	GEM_S23 →	+0.735	+0.059	<.001	<.001	3	6
COAD	GUCY1A1 →	+0.519	+0.045	<.001	<.001	3	6
LUAD	PLEC_T3879 →	+0.645	+0.072	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034139 vs SRC — OV

Explore this scatter interactively →