Regulation of toll-like receptor 3 signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of toll-like receptor 3 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIM3, DIXDC1, and IFNL3P1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of toll-like receptor 3 signaling pathway activity versus TRIM3 in BRCA (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TRIM3 →	+0.653	+0.187	<.001	<.001	3	6
UCEC	DIXDC1 →	+0.560	+0.213	<.001	<.001	3	4
LUAD	IFNL3P1 →	-0.297	-0.074	.009	.009	3	3
BRCA	SMIM14 →	+0.917	+0.232	.002	<.001	3	3
COAD	IPO7P2 →	+0.317	+0.147	<.001	<.001	3	3
BRCA	REC8 →	-0.755	-0.221	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034139 vs TRIM3 — BRCA

Explore this scatter interactively →