Regulation of toll-like receptor 3 signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of toll-like receptor 3 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALKBH3, HYOU1, and SLC22A17, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ALKBH3 grouped by Regulation of toll-like receptor 3 signaling pathway-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ALKBH3 →	-1.073	-0.384	.001	.006	3	5
PANCREAS	HYOU1 →	-0.925	-0.773	.004	.003	3	4
UPPER_AERODIGESTIVE_TRACT	SLC22A17 →	-2.100	-0.406	<.001	<.001	3	4
LIVER	FIBCD1 →	-2.235	-0.324	.003	.001	3	4
PANCREAS	SLC41A3 →	-0.818	-1.018	.003	.006	3	3
STOMACH	DNAJC11 →	+0.565	+0.705	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ALKBH3 by Regulation of toll-like receptor 3 signaling pathway activity — BLOOD_Myeloma

Explore this box plot interactively →