Regulation of toll-like receptor 3 signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of toll-like receptor 3 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APOO, ZNF618, and MRPL37, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of toll-like receptor 3 signaling pathway activity versus APOO in PANCREAS (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	APOO →	+1.140	+1.011	.002	.008	3	6
PANCREAS	ZNF618 →	+2.036	+1.535	.006	.004	3	5
PANCREAS	MRPL37 →	+0.976	+1.459	<.001	<.001	3	5
LARGE_INTESTINE	INPP4B →	-1.139	-0.837	<.001	<.001	3	5
LARGE_INTESTINE	C20orf96 →	+1.013	+1.070	.003	<.001	3	5
STOMACH	NABP2 →	+0.756	+1.079	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034139 vs APOO — PANCREAS

Explore this scatter interactively →