Toll-like receptor 3 signaling pathway

Across TCGA cell cohorts, RNA activity of the Toll-like receptor 3 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRF1, OAS1, and PSMB9, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Toll-like receptor 3 signaling pathway activity versus IRF1 in SOFT_TISSUE (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	IRF1 →	+1.933	+0.135	<.001	<.001	3	16
OESOPHAGUS	OAS1 →	+3.252	+0.175	<.001	<.001	3	16
SOFT_TISSUE	PSMB9 →	+2.696	+0.131	<.001	<.001	3	16
BONE	SP100 →	+2.804	+0.102	<.001	<.001	3	15
SOFT_TISSUE	OAS2 →	+2.224	+0.113	<.001	<.001	3	14
BONE	MVP →	+3.565	+0.123	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034138 vs IRF1 — SOFT_TISSUE

Explore this scatter interactively →