Toll-like receptor 2 signaling pathway

Across TCGA cell cohorts, RNA activity of the Toll-like receptor 2 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIM7, ECH1, and ATAD3A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRIM7 grouped by Toll-like receptor 2 signaling pathway-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TRIM7 →	-2.245	-1.276	.001	.006	3	4
OVARY	ECH1 →	-1.049	-1.013	.005	.004	3	4
OVARY	ATAD3A →	+0.571	+0.774	<.001	.007	3	4
LUNG_NSCLC_LUSC	ALOXE3 →	-0.521	-1.832	.003	<.001	3	4
BONE	HADHB →	-0.466	-1.425	<.001	.004	3	3
SKIN	CDKN1A →	-2.855	-1.265	<.001	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRIM7 by Toll-like receptor 2 signaling pathway activity — SOFT_TISSUE

Explore this box plot interactively →