Toll-like receptor 2 signaling pathway

Across TCGA cell cohorts, RNA activity of the Toll-like receptor 2 signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARID1A, ZNF875, and CCT5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARID1A grouped by Toll-like receptor 2 signaling pathway-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ARID1A →	-0.281	-0.187	.001	.003	3	5
BONE	ZNF875 →	-0.210	-0.228	.006	.002	3	5
LUNG_NSCLC_LUSC	CCT5 →	+0.495	+0.228	.003	.005	3	4
BONE	B3GNT2 →	-0.472	-0.168	.004	.006	3	4
LUNG_NSCLC_LUSC	AMH →	+0.293	+0.204	<.001	.002	3	4
BLOOD_Myeloma	ANKRD20A4P →	-0.162	-0.112	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARID1A by Toll-like receptor 2 signaling pathway activity — URINARY_TRACT

Explore this box plot interactively →