Toll-like receptor 2 signaling pathway

Across TCGA cell cohorts, RNA activity of the Toll-like receptor 2 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GATAD2A, LSM2, and MANSC4, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Toll-like receptor 2 signaling pathway activity versus GATAD2A in BLOOD_Lymphoma (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GATAD2A →	+0.874	+1.326	<.001	<.001	3	2
BLOOD_Leukemia	LSM2 →	+0.939	+0.391	<.001	.004	3	1
BLOOD_Leukemia	MANSC4 →	-0.126	-0.376	<.001	.004	3	1
BLOOD_Leukemia	DTNBP1 →	+1.133	+0.298	.007	.007	3	1
BLOOD_Leukemia	FMO4 →	-0.620	-0.220	.002	<.001	3	1
BLOOD_Leukemia	NRF1 →	+0.802	+0.400	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034134 vs GATAD2A — BLOOD_Lymphoma

Explore this scatter interactively →