Negative regulation of toll-like receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of toll-like receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the KIRC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LENG8, ZNF169, and LY6G5B, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of toll-like receptor signaling pathway activity versus LENG8 in KIRC (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRC	LENG8 →	+1.277	+0.039	<.001	<.001	3	28
THYM	ZNF169 →	+0.588	+0.031	<.001	<.001	3	27
KIRC	LY6G5B →	+1.004	+0.037	<.001	<.001	3	27
SCLC	DENND3 →	+0.850	+0.118	<.001	<.001	3	26
KIRP	GPS2 →	+0.965	+0.044	<.001	<.001	3	26
LAML	FGD2 →	+1.264	+0.051	<.001	<.001	3	26

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034122 vs LENG8 — KIRC

Explore this scatter interactively →