Negative regulation of toll-like receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of toll-like receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EVI2B, SPN, and CD48, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of toll-like receptor signaling pathway activity versus EVI2B in BRCA (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EVI2B →	+0.600	+0.047	<.001	<.001	3	9
UCEC	SPN →	+0.750	+0.072	<.001	.009	3	8
OV	CD48 →	+0.790	+0.030	.004	.004	3	8
GBM	DEF6_S590 →	+0.712	+0.065	.008	.007	3	8
UCEC	FYB1 →	+0.546	+0.067	<.001	<.001	3	8
BRCA	ITGAL →	+0.499	+0.038	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034122 vs EVI2B — BRCA

Explore this scatter interactively →