Negative regulation of toll-like receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of toll-like receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DOK3, CACNA1D, and KMT5B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of toll-like receptor signaling pathway activity versus DOK3 in UCEC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DOK3 →	+0.631	+0.177	.001	.005	3	4
PDAC	CACNA1D →	-0.609	-0.203	<.001	<.001	3	4
UCEC	KMT5B →	-0.331	-0.169	.002	.009	3	3
UCEC	LILRB2 →	+0.746	+0.180	.001	.005	3	3
LUAD	LGALSL →	-0.594	-0.285	.003	.003	3	3
COAD	ASB13 →	-0.389	-0.713	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034122 vs DOK3 — UCEC

Explore this scatter interactively →