Negative regulation of toll-like receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of toll-like receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDYL, OARD1, and MAPK1IP1L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDYL grouped by Negative regulation of toll-like receptor signaling pathway-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CDYL →	-0.532	-0.858	<.001	<.001	3	3
OVARY	OARD1 →	+0.641	+0.938	.002	.005	3	3
OVARY	MAPK1IP1L →	-0.690	-1.025	<.001	.003	2	4
KIDNEY	GNPTG →	-0.676	-1.070	.003	.007	3	3
LUNG_NSCLC_LUSC	EPOP →	-1.096	-1.210	<.001	.003	3	3
LUNG_NSCLC_LUAD	JAG1 →	-1.268	-0.627	.001	.002	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDYL by Negative regulation of toll-like receptor signaling pathway activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →