Negative regulation of toll-like receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of toll-like receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STX2, SRGN, and CDKN1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of toll-like receptor signaling pathway activity versus STX2 in OVARY (Pearson r = -0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	STX2 →	-1.471	-0.328	.001	<.001	3	5
OVARY	SRGN →	-4.221	-0.282	.002	.004	3	4
OVARY	CDKN1A →	-2.407	-0.268	.004	.005	3	4
PANCREAS	KRT7 →	-4.404	-0.284	.007	.006	3	4
PANCREAS	MRPL39 →	+0.679	+0.330	.004	.002	3	4
PANCREAS	NPM2 →	-2.230	-0.386	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034122 vs STX2 — OVARY

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