Regulation of toll-like receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of toll-like receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN1, SKAP2, and STK10, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of toll-like receptor signaling pathway activity versus SEPTIN1 in BRCA (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SEPTIN1 →	+0.809	+0.046	<.001	<.001	3	9
GBM	SKAP2 →	+0.668	+0.063	<.001	<.001	3	9
LSCC	STK10 →	+0.337	+0.056	<.001	<.001	3	9
OV	THEMIS2_T593 →	+0.758	+0.033	.002	<.001	3	9
BRCA	WAS →	+0.512	+0.047	<.001	<.001	3	9
OV	CD48 →	+0.765	+0.037	.002	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034121 vs SEPTIN1 — BRCA

Explore this scatter interactively →