Regulation of toll-like receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of toll-like receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOX13, ANK3, and CLEC4E, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of toll-like receptor signaling pathway activity versus SOX13 in BRCA (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SOX13 →	-0.644	-0.614	.003	.004	2	5
PDAC	ANK3 →	-0.408	-0.276	.002	.005	3	4
BRCA	CLEC4E →	+0.522	+0.444	.007	.006	3	3
LSCC	ENTPD3 →	-1.039	-0.891	<.001	.001	2	4
BRCA	FCGR1B →	+0.405	+0.608	.002	.008	3	3
UCEC	POC1B-GALNT4 →	-0.361	-0.215	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034121 vs SOX13 — BRCA

Explore this scatter interactively →