Regulation of toll-like receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of toll-like receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIGQ, SELPLG, and CYP2D7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PIGQ grouped by Regulation of toll-like receptor signaling pathway-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PIGQ →	-0.672	-1.105	.001	.003	3	4
OVARY	SELPLG →	-1.133	-1.223	.007	.002	3	4
BREAST	CYP2D7 →	+0.687	+0.758	.003	.005	3	4
LUNG_SCLC	RRP9 →	-0.818	-0.956	.007	.002	3	3
KIDNEY	HSP90B1 →	+0.780	+1.001	<.001	<.001	3	3
KIDNEY	DECR2 →	-1.190	-1.137	<.001	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PIGQ by Regulation of toll-like receptor signaling pathway activity — PANCREAS

Explore this box plot interactively →