Regulation of toll-like receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of toll-like receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACP1, ZFX, and RNF167, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of toll-like receptor signaling pathway activity versus ACP1 in LARGE_INTESTINE (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACP1 →	+0.415	+0.156	<.001	.006	2	7
PANCREAS	ZFX →	+0.841	+0.220	.005	.009	3	6
BLOOD_Leukemia	RNF167 →	+0.879	+0.269	<.001	.004	3	5
KIDNEY	ATP8B3 →	-0.931	-0.146	.009	.003	3	5
LIVER	PRPF8 →	+0.652	+0.334	.003	.003	2	6
BLOOD_Myeloma	TIMM22 →	+0.772	+0.292	.003	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034121 vs ACP1 — LARGE_INTESTINE

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