Positive regulation of heterotypic cell-cell adhesion

Across TCGA patient cohorts, RNA activity of the Positive regulation of heterotypic cell-cell adhesion pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL2RA, JAK3, and MT2A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of heterotypic cell-cell adhesion activity versus IL2RA in GBM (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	IL2RA →	+0.918	+0.132	<.001	<.001	3	5
GBM	JAK3 →	+0.664	+0.135	<.001	<.001	3	5
GBM	MT2A →	+0.911	+0.106	<.001	<.001	3	5
GBM	FCGR2A →	+0.739	+0.122	<.001	<.001	3	5
GBM	ARHGAP30 →	+0.735	+0.177	<.001	<.001	3	5
GBM	IL21R →	+1.084	+0.187	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034116 vs IL2RA — GBM

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