Positive regulation of heterotypic cell-cell adhesion

Across TCGA cell cohorts, RNA activity of the Positive regulation of heterotypic cell-cell adhesion pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNF, GPR162, and IL1B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TNF grouped by Positive regulation of heterotypic cell-cell adhesion-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	TNF →	-0.201	-1.548	.007	<.001	3	6
CNS	GPR162 →	-0.391	-1.054	.001	.001	3	6
OVARY	IL1B →	-0.414	-1.108	<.001	.002	3	6
BREAST	CCR7 →	-0.175	-0.817	<.001	.003	3	6
LARGE_INTESTINE	CD44 →	-0.257	-0.705	.001	.002	2	6
LUNG_SCLC	PEX1 →	-0.386	-1.095	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TNF by Positive regulation of heterotypic cell-cell adhesion activity — BLOOD_Myeloma

Explore this box plot interactively →