Regulation of heterotypic cell-cell adhesion

Across TCGA cell cohorts, RNA activity of the Regulation of heterotypic cell-cell adhesion pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAP1, CCDC88C, and HSPA9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CAP1 grouped by Regulation of heterotypic cell-cell adhesion-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CAP1 →	-0.636	-0.682	.002	.003	3	4
CNS	CCDC88C →	+1.393	+0.944	.002	.003	3	4
LUNG_SCLC	HSPA9 →	-0.669	-1.172	.001	.003	3	4
STOMACH	NOTCH2 →	-1.374	-0.675	.001	.004	3	4
BLOOD_Leukemia	C16orf95 →	-0.575	-0.587	.003	.003	3	3
BLOOD_Leukemia	PRDM1 →	+1.026	+0.256	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CAP1 by Regulation of heterotypic cell-cell adhesion activity — CNS

Explore this box plot interactively →