Regulation of heterotypic cell-cell adhesion

Across TCGA cell cohorts, RNA activity of the Regulation of heterotypic cell-cell adhesion pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD44, SMIM22, and C2orf15, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of heterotypic cell-cell adhesion activity versus CD44 in BONE (Pearson r = 0.91).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CD44 →	+6.630	+1.947	.006	<.001	2	8
LUNG_SCLC	SMIM22 →	-3.797	-1.261	.001	.001	3	6
LUNG_SCLC	C2orf15 →	-1.927	-1.261	<.001	.001	3	5
URINARY_TRACT	AKTIP →	-0.924	-0.392	<.001	.004	3	5
LUNG_SCLC	CHST3 →	+2.552	+1.453	.005	.004	3	4
LUNG_SCLC	HLX →	+1.498	+1.551	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034114 vs CD44 — BONE

Explore this scatter interactively →