Heterotypic cell-cell adhesion

Across TCGA patient cohorts, RNA activity of the Heterotypic cell-cell adhesion pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STK10, THEMIS2_T593, and TNFAIP8L2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heterotypic cell-cell adhesion activity versus STK10 in LSCC (Pearson r = 0.52).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	STK10 →	+0.413	+0.056	<.001	<.001	3	10
LSCC	THEMIS2_T593 →	+0.829	+0.069	<.001	<.001	3	10
GBM	TNFAIP8L2 →	+0.534	+0.050	<.001	<.001	3	10
HNSC	WAS →	+0.528	+0.049	<.001	.009	3	10
UCEC	WIPF1 →	+0.485	+0.083	<.001	<.001	3	10
CCRCC	DEF6 →	+0.532	+0.064	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034113 vs STK10 — LSCC

Explore this scatter interactively →