Heterotypic cell-cell adhesion

Across TCGA cell cohorts, RNA activity of the Heterotypic cell-cell adhesion pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEX3B, LSR, and ITGB6, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heterotypic cell-cell adhesion activity versus MEX3B in URINARY_TRACT (Pearson r = -0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	MEX3B →	-1.556	-0.368	<.001	.003	3	9
LUNG_NSCLC_LUAD	LSR →	+2.865	+0.438	<.001	<.001	3	8
URINARY_TRACT	ITGB6 →	+5.005	+0.600	<.001	<.001	3	8
PANCREAS	GALNT3 →	+4.229	+0.552	<.001	<.001	3	8
URINARY_TRACT	EPHA1 →	+3.670	+0.513	.002	.002	3	8
LUNG_NSCLC_LUAD	CLDN7 →	+4.031	+0.336	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034113 vs MEX3B — URINARY_TRACT

Explore this scatter interactively →