Positive regulation of homotypic cell-cell adhesion

Across TCGA patient cohorts, RNA activity of the Positive regulation of homotypic cell-cell adhesion pathway is significantly associated with the RNA expression of multiple genes, with the BLCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FCER1G, LILRB2, and EMILIN2, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of homotypic cell-cell adhesion activity versus FCER1G in BLCA (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	FCER1G →	+2.112	+0.077	<.001	<.001	3	32
SCLC	LILRB2 →	+1.600	+0.206	<.001	<.001	3	32
ACC	EMILIN2 →	+1.652	+0.056	<.001	<.001	3	31
DLBC	HK3 →	+1.994	+0.119	<.001	<.001	3	31
SCLC	FPR1 →	+2.139	+0.158	<.001	<.001	3	31
LAML	NFAM1 →	+2.085	+0.086	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034112 vs FCER1G — BLCA

Explore this scatter interactively →