Positive regulation of homotypic cell-cell adhesion

Across TCGA patient cohorts, RNA activity of the Positive regulation of homotypic cell-cell adhesion pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANK3, MFSD4A, and ARL4AP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of homotypic cell-cell adhesion activity versus ANK3 in GBM (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ANK3 →	+0.911	+0.765	<.001	<.001	3	6
LUAD	MFSD4A →	+1.565	+0.171	<.001	.005	3	4
LSCC	ARL4AP1 →	+0.738	+0.358	<.001	<.001	3	4
GBM	CRYM →	+1.511	+0.783	<.001	<.001	3	3
UCEC	PNO1 →	-0.516	-0.613	<.001	.001	2	4
OV	CSTF3-DT →	-0.102	-0.348	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034112 vs ANK3 — GBM

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