Positive regulation of homotypic cell-cell adhesion

Across TCGA cell cohorts, RNA activity of the Positive regulation of homotypic cell-cell adhesion pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEAK7, TPP2, and PDSS2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MEAK7 grouped by Positive regulation of homotypic cell-cell adhesion-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MEAK7 →	-1.440	-0.464	<.001	.001	3	3
LUNG_NSCLC_LUSC	TPP2 →	+0.531	+0.291	<.001	.001	2	4
LUNG_NSCLC_LUSC	PDSS2 →	+0.765	+0.259	.001	.006	3	3
LUNG_NSCLC_LUSC	HACE1 →	+0.785	+0.309	.004	.003	3	3
BONE	DUS2 →	-0.519	-0.312	.006	.008	3	3
BONE	KIRREL1 →	-2.116	-0.409	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MEAK7 by Positive regulation of homotypic cell-cell adhesion activity — PANCREAS

Explore this box plot interactively →