Positive regulation of homotypic cell-cell adhesion

Across TCGA cell cohorts, RNA activity of the Positive regulation of homotypic cell-cell adhesion pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAK6, F11R, and CDH3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of homotypic cell-cell adhesion activity versus PAK6 in LUNG_NSCLC_LUAD (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PAK6 →	+2.136	+0.797	<.001	.004	3	8
LUNG_NSCLC_LUAD	F11R →	+2.047	+0.794	<.001	<.001	3	7
LUNG_NSCLC_LUAD	CDH3 →	+3.811	+0.780	<.001	<.001	3	7
OVARY	PPL →	+3.172	+0.852	<.001	.006	3	7
LUNG_NSCLC_LUAD	ARHGAP8 →	+1.957	+0.715	<.001	<.001	3	7
LUNG_NSCLC_LUAD	CDH1 →	+3.893	+0.956	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034112 vs PAK6 — LUNG_NSCLC_LUAD

Explore this scatter interactively →