Regulation of homotypic cell-cell adhesion

Across TCGA patient cohorts, RNA activity of the Regulation of homotypic cell-cell adhesion pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANK3, HMMR, and MFNG, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of homotypic cell-cell adhesion activity versus ANK3 in CCRCC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ANK3 →	+0.652	+0.149	.007	.006	3	5
GBM	HMMR →	-0.654	-0.973	.009	.001	3	5
GBM	MFNG →	+0.487	+0.911	<.001	<.001	3	5
GBM	GYPC →	+0.669	+0.870	.008	.003	3	5
GBM	PGM5 →	+0.640	+0.837	<.001	.001	3	5
LSCC	FRZB →	+0.633	+0.175	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034110 vs ANK3 — CCRCC

Explore this scatter interactively →