Regulation of homotypic cell-cell adhesion

Across TCGA cell cohorts, RNA activity of the Regulation of homotypic cell-cell adhesion pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRELID3B, PHF7, and PM20D2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRELID3B grouped by Regulation of homotypic cell-cell adhesion-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PRELID3B →	+0.472	+0.827	.008	<.001	3	4
BLOOD_Leukemia	PHF7 →	+1.033	+1.313	.009	.003	3	3
BLOOD_Leukemia	PM20D2 →	+2.091	+1.387	<.001	<.001	2	4
BLOOD_Leukemia	RPIA →	+0.669	+1.065	.006	.006	3	3
BLOOD_Leukemia	PDLIM7 →	-0.883	-1.167	.002	.002	3	3
SKIN	YEATS2 →	+0.407	+0.862	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRELID3B by Regulation of homotypic cell-cell adhesion activity — SKIN

Explore this box plot interactively →