Regulation of homotypic cell-cell adhesion

Across TCGA cell cohorts, RNA activity of the Regulation of homotypic cell-cell adhesion pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHKA, RRM2, and ANKRD39, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of homotypic cell-cell adhesion activity versus CHKA in STOMACH (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CHKA →	+1.109	+0.367	.007	<.001	3	5
OVARY	RRM2 →	-1.302	-0.626	<.001	.008	3	5
OVARY	ANKRD39 →	-0.832	-0.880	.002	.006	3	5
OESOPHAGUS	FGFBP1 →	+5.237	+0.450	<.001	<.001	3	5
LUNG_SCLC	SORT1 →	+0.507	+0.352	.009	.006	3	5
LUNG_NSCLC_LUAD	PAK6 →	+1.416	+0.606	.002	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034110 vs CHKA — STOMACH

Explore this scatter interactively →