Homotypic cell-cell adhesion

Across TCGA patient cohorts, RNA activity of the Homotypic cell-cell adhesion pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ANKRD44, TBC1D2B, and PLEKHO2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Homotypic cell-cell adhesion activity versus ANKRD44 in LSCC (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ANKRD44 →	+0.408	+0.050	<.001	<.001	3	10
GBM	TBC1D2B →	+0.405	+0.091	<.001	<.001	3	9
OV	PLEKHO2 →	+0.473	+0.054	<.001	<.001	3	9
GBM	LCP1 →	+0.959	+0.101	<.001	<.001	3	9
GBM	ARHGAP25 →	+0.475	+0.076	<.001	<.001	3	9
GBM	ARHGAP30 →	+0.794	+0.095	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034109 vs ANKRD44 — LSCC

Explore this scatter interactively →