Homotypic cell-cell adhesion

Across TCGA patient cohorts, RNA activity of the Homotypic cell-cell adhesion pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAGLN, TPM2, and STMN2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Homotypic cell-cell adhesion activity versus TAGLN in CCRCC (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TAGLN →	+1.308	+0.257	<.001	<.001	3	3
BRCA	TPM2 →	+0.767	+0.156	.006	.005	3	3
CCRCC	STMN2 →	+0.437	+0.150	.004	.008	3	3
CCRCC	SULF1 →	+0.895	+0.197	<.001	<.001	3	3
CCRCC	LUM →	+1.546	+0.164	.006	.003	3	3
CCRCC	CPNE2 →	+0.292	+0.151	.006	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034109 vs TAGLN — CCRCC

Explore this scatter interactively →