Homotypic cell-cell adhesion

Across TCGA cell cohorts, RNA activity of the Homotypic cell-cell adhesion pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHF23, ACAT2, and MBTD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PHF23 grouped by Homotypic cell-cell adhesion-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PHF23 →	-0.795	-0.247	<.001	.007	3	4
OVARY	ACAT2 →	-1.291	-0.967	<.001	.006	3	3
LUNG_SCLC	MBTD1 →	-1.009	-0.317	.007	.001	3	3
LUNG_SCLC	MATR3 →	-0.553	-0.285	.007	.008	3	3
LUNG_SCLC	ZNF491 →	-1.230	-0.296	<.001	.001	3	3
LUNG_NSCLC_LUAD	BEND3 →	-0.315	-0.497	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PHF23 by Homotypic cell-cell adhesion activity — LARGE_INTESTINE

Explore this box plot interactively →