Homotypic cell-cell adhesion

Across TCGA cell cohorts, RNA activity of the Homotypic cell-cell adhesion pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KANK1, NEDD9, and RAB25, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Homotypic cell-cell adhesion activity versus KANK1 in SOFT_TISSUE (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KANK1 →	+3.314	+0.225	.004	.001	3	6
LARGE_INTESTINE	NEDD9 →	+1.936	+0.148	<.001	<.001	3	5
LUNG_NSCLC_LUAD	RAB25 →	+3.611	+0.148	<.001	.005	3	5
URINARY_TRACT	PLEKHF2 →	+1.152	+0.214	.001	.002	3	5
BONE	TC2N →	+0.358	+0.285	<.001	.003	3	5
BONE	STX19 →	+0.070	+0.261	.004	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034109 vs KANK1 — SOFT_TISSUE

Explore this scatter interactively →