Negative regulation of tissue remodeling

Across TCGA patient cohorts, RNA activity of the Negative regulation of tissue remodeling pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FNBP1, LCP1, and MYO1G, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of tissue remodeling activity versus FNBP1 in LSCC (Pearson r = 0.62).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FNBP1 →	+0.374	+0.075	<.001	<.001	3	10
GBM	LCP1 →	+0.764	+0.104	<.001	<.001	3	10
GBM	MYO1G →	+0.660	+0.093	<.001	<.001	3	10
HNSC	TRAF3IP3 →	+0.566	+0.058	.002	.003	3	9
UCEC	WDFY4 →	+0.542	+0.091	<.001	<.001	3	9
OV	CD48 →	+0.903	+0.056	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034104 vs FNBP1 — LSCC

Explore this scatter interactively →