Negative regulation of tissue remodeling

Across TCGA cell cohorts, RNA activity of the Negative regulation of tissue remodeling pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIMP3, P2RX7, and TSC22D4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TIMP3 grouped by Negative regulation of tissue remodeling-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TIMP3 →	-0.327	-1.374	.001	<.001	3	6
SOFT_TISSUE	P2RX7 →	-0.287	-1.440	.004	<.001	3	5
SKIN	TSC22D4 →	-0.245	-1.131	.001	.008	3	5
OESOPHAGUS	CD38 →	-0.120	-0.536	.005	.003	2	6
BREAST	GREM1 →	-0.313	-1.241	<.001	<.001	3	5
BREAST	DPM2 →	-0.197	-0.775	.001	.007	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TIMP3 by Negative regulation of tissue remodeling activity — PANCREAS

Explore this box plot interactively →