Negative regulation of tissue remodeling

Across TCGA cell cohorts, RNA activity of the Negative regulation of tissue remodeling pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKR1C1, CDC37L1, and NEK3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of tissue remodeling activity versus AKR1C1 in STOMACH (Pearson r = -0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	AKR1C1 →	-4.366	-1.512	.004	.004	3	4
UPPER_AERODIGESTIVE_TRACT	CDC37L1 →	-0.677	-1.628	.004	<.001	3	4
BLOOD_Lymphoma	NEK3 →	-0.999	-0.533	.009	.004	3	4
BLOOD_Lymphoma	RBM43 →	-1.064	-0.555	<.001	.003	3	4
BLOOD_Lymphoma	AIDA →	-0.858	-0.806	.005	.009	2	5
BLOOD_Lymphoma	VMP1 →	-1.520	-0.736	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034104 vs AKR1C1 — STOMACH

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