Regulation of tissue remodeling

Across TCGA cell cohorts, RNA activity of the Regulation of tissue remodeling pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRRK1, TPRG1L, and TMEM145, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LRRK1 grouped by Regulation of tissue remodeling-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	LRRK1 →	-1.445	-0.866	.002	.004	3	3
CNS	TPRG1L →	-0.532	-0.662	.003	.009	3	3
CNS	TMEM145 →	+0.637	+0.907	.006	.003	3	3
CNS	PLEKHO2 →	-0.770	-0.671	.001	.008	3	3
LARGE_INTESTINE	TMEM52 →	+1.102	+1.060	.009	.001	3	3
OESOPHAGUS	KAT8 →	+0.856	+1.534	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LRRK1 by Regulation of tissue remodeling activity — CNS

Explore this box plot interactively →