Erythrocyte homeostasis

Across TCGA patient cohorts, RNA activity of the Erythrocyte homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CACNA2D1, TLN1, and TNS1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Erythrocyte homeostasis activity versus CACNA2D1 in OV (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CACNA2D1 →	+0.664	+0.047	<.001	<.001	3	8
OV	TLN1 →	+0.361	+0.047	<.001	<.001	3	8
BRCA	TNS1 →	+0.362	+0.022	<.001	<.001	3	8
OV	EIF3G →	-0.291	-0.046	<.001	<.001	3	8
BRCA	ABI3BP →	+1.040	+0.046	<.001	<.001	3	8
HNSC	LAMB2 →	+0.776	+0.047	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034101 vs CACNA2D1 — OV

Explore this scatter interactively →