Erythrocyte homeostasis

Across TCGA patient cohorts, RNA activity of the Erythrocyte homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MASP1, C6orf47, and RPL7P13, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Erythrocyte homeostasis activity versus MASP1 in PDAC (Pearson r = -0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	MASP1 →	-0.268	-0.218	.006	.009	3	2
COAD	C6orf47 →	+0.232	+0.126	.008	.007	3	2
COAD	RPL7P13 →	-0.113	-0.165	.007	.005	3	2
COAD	MIR4999 →	+0.411	+0.159	<.001	.004	3	2
COAD	ARF4P1 →	-0.349	-0.137	.001	.003	3	2
BRCA	XCL2 →	+1.424	+0.243	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034101 vs MASP1 — PDAC

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